Five Silver Bullets in cEDH

cEDH is a best-of-one format filled with niche decks and packed to the brim with variance, all things that making tuning a deck against the broader meta difficult, to say the least. Sure, the format has its all-stars - Blue Farm, RogSi, and now Nadu, Winged Wisdom
Silver bullets are cards which aren't focused on advancing your own gameplan but are instead targeted responses to some of the most popular threats in the meta. While these kinds of cards are definitely stax-like in nature, make no mistake: running them does not make you a stax deck. Instead, think of them like narrow interaction, but that narrow nature is made up for by the explosive impact they can have on the game when they do activate. With that in mind, here are five of the best silver bullets in cEDH.
#5 - An Extra Board Wipe
Coming in at number five is a bit of a catch-all, a flex slot meant to deal with the bevy of creature-based decks running rampant across cEDH write now. I've already written about how Nadu has renewed the call for board wipes, but it's worth reiterating: sometimes, not every threat can be answered with spot removal.
cEDH's most notorious creatures are often united in their ability to be relevant the turn they come down, but it's important to note that immediate relevancy doesn't necessarily translate to single-turn relevancy. For every Dockside Extortionist
Board wipes also reset the individually-insignificant-yet-en-masse-crucial creatures that often squeak by unnoticed. You'll certainly knock the wind out of a Kinnan, Bonder Prodigy
#4 - Opposition Agent
Next up on our list is a creature that I used to think was just an overall black staple, but has fallen out of favor recently thanks to its rather large high mana cost: Opposition Agent
Now, I know that three mana isn't the worst thing in the world, especially when it's on a creature with as powerful text as Opposition Agent's ability to steal your opponents' tutors, but the issue here is that Opposition Agent is a spell you have to hold up as if it's interaction, because that's really what it is. Playing an Opposition Agent early diminishes its effect, as it negates the "Gotcha" aspect of the card. Don't get me wrong, Opposition Agent is a great card; it's just a bit clunky to actually use in practice, which is why I wouldn't count it as a ubiquitous staple. However, as a silver bullet it's not just great, it's fantastic. Why? Because Sisay, Weatherlight Captain
Sisay is a deck that is entirely focused on its commander's tutor ability, meaning an Opposition Agent in play shuts the deck down hard. Given Sisay's prominence in the meta (routinely being ranked as one of cEDH's tier one decks), it's safe to say that any silver bullet which could take it down, especially one as generically good as Opposition Agent, is worth considering.
#3 - Manglehorn
Similar to our number five pick, this selection is also a bit of an umbrella, covering anything and everything that hates on artifacts. The reason I picked Manglehorn, however, is that it belongs to a small subset of artifact hate that is one-sided; see Dauntless Dismantler
Artifacts are pretty good in cEDH. Lion's Eye Diamond
First, the enter-the-battlefield trigger. This is the least important effect of Manglehorn, but there will be opportunities when it comes in handy. Setting an opponent back a Sol Ring is always good, so this incidental bonus shouldn't be completely dismissed when considering Manglehorn's value.
Second, the static ability of causing artifacts to enter the battlefield tapped. This effectively shuts off combos involving Dockside Extortionist, one of cEDH's most prevalent threats, while also turning rocks into dorks thanks to what is effectively summoning sickness. Also, as a little bonus, Mana Vault
Third, the keywords "opponents control." While this is technically a part of Manglehorn's second (and final) ability, these two words warrant their own discussion, so let's get to it. Above all else, silver bullets are about breaking parity while inflicting as little, if any, deckbuilding constraints upon their user. Collector Ouphe
#2 - Cursed Totem
Remember everything I just said about parity and deckbuilding constraints? Cursed Totem contains no such "opponents control" language anywhere on it, so understanding this card's importance is going to be heavily meta-dependent.
The impact of activated abilities from creatures in cEDH is incredibly varied. Some decks use them with great impact, like Sisay and Kinnan, but for most decks the actual count of creatures with relevant activated abilities is pretty low, so, unlike artifacts, which are a dime a dozen, most decklists are already optimized so as to not care about activated abilities; at least, not that much. Sure, it sucks to be unable to crack a Ranger-Captain of Eos
This means that the average deck falls into one of two categories: those that couldn't care less about Cursed Totem, and those that care a whole lot. Between Sisay, Kinnan, and Najeela, the Blade-Blossom
#1 - Drannith Magistrate
Just like Opposition Agent, I used to think that Drannith Magistrate was a white staple, but alas, times change, lists evolve, and now we see it on the silver bullets list. Players just don't want to be as responsible, I guess. That being said, Drannith Magistrate still pacts an incredible punch regardless of where its used, so let's get into it.
For two mana, Drannith Magistrate is a 1/3 Human Wizard that shuts off your opponents' abilities to cast spells from anywhere other than their hands. That means no graveyards (see you later, Underworld Breach
Wrap Up
No two cEDH games are alike, but there are plenty of common themes among them. Artifacts are good, as are Underworld Breach